New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities
Eleven new polyphenols namely spiromastols A–K (1–11) were isolated from the fermentation broth of a deep sea-derived fungus Spiromastix sp. MCCC 3A00308. Their structures were determined by extensive NMR data and mass spectroscopic analysis in association with chemical conversion. The structures...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-04-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/13/4/2526 |
| _version_ | 1817995952182525952 |
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| author | Siwen Niu Dong Liu Peter Proksch Zongze Shao Wenhan Lin |
| author_facet | Siwen Niu Dong Liu Peter Proksch Zongze Shao Wenhan Lin |
| author_sort | Siwen Niu |
| collection | DOAJ |
| description | Eleven new polyphenols namely spiromastols A–K (1–11) were isolated from the fermentation broth of a deep sea-derived fungus Spiromastix sp. MCCC 3A00308. Their structures were determined by extensive NMR data and mass spectroscopic analysis in association with chemical conversion. The structures are classified as diphenyl ethers, diphenyl esters and isocoumarin derivatives, while the n-propyl group in the analogues is rarely found in natural products. Compounds 1–3 exhibited potent inhibitory effects against a panel of bacterial strains, including Xanthomanes vesicatoria, Pseudomonas lachrymans, Agrobacterium tumefaciens, Ralstonia solanacearum, Bacillus thuringensis, Staphylococcus aureus and Bacillus subtilis, with minimal inhibitory concentration (MIC) values ranging from 0.25 to 4 µg/mL. The structure-activity relationships are discussed, while the polychlorinated analogues 1–3 are assumed to be a promising structural model for further development as antibacterial agents. |
| first_indexed | 2024-04-14T02:14:38Z |
| format | Article |
| id | doaj.art-9dfdf860b0784a3dbb79a1644b9f1cdc |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T02:14:38Z |
| publishDate | 2015-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-9dfdf860b0784a3dbb79a1644b9f1cdc2022-12-22T02:18:16ZengMDPI AGMarine Drugs1660-33972015-04-011342526254010.3390/md13042526md13042526New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial ActivitiesSiwen Niu0Dong Liu1Peter Proksch2Zongze Shao3Wenhan Lin4College of Marine Life, Ocean University of China, Qingdao 266003, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, ChinaInstitute für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, Geb.26.23, 40225 Düsseldorf, GermanyCollege of Marine Life, Ocean University of China, Qingdao 266003, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, ChinaEleven new polyphenols namely spiromastols A–K (1–11) were isolated from the fermentation broth of a deep sea-derived fungus Spiromastix sp. MCCC 3A00308. Their structures were determined by extensive NMR data and mass spectroscopic analysis in association with chemical conversion. The structures are classified as diphenyl ethers, diphenyl esters and isocoumarin derivatives, while the n-propyl group in the analogues is rarely found in natural products. Compounds 1–3 exhibited potent inhibitory effects against a panel of bacterial strains, including Xanthomanes vesicatoria, Pseudomonas lachrymans, Agrobacterium tumefaciens, Ralstonia solanacearum, Bacillus thuringensis, Staphylococcus aureus and Bacillus subtilis, with minimal inhibitory concentration (MIC) values ranging from 0.25 to 4 µg/mL. The structure-activity relationships are discussed, while the polychlorinated analogues 1–3 are assumed to be a promising structural model for further development as antibacterial agents.http://www.mdpi.com/1660-3397/13/4/2526fungus from deep seaSpiromastix sp.spiromastols A–Kpolyphenolsantibacterial activities |
| spellingShingle | Siwen Niu Dong Liu Peter Proksch Zongze Shao Wenhan Lin New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities Marine Drugs fungus from deep sea Spiromastix sp. spiromastols A–K polyphenols antibacterial activities |
| title | New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities |
| title_full | New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities |
| title_fullStr | New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities |
| title_full_unstemmed | New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities |
| title_short | New Polyphenols from a Deep Sea Spiromastix sp. Fungus, and Their Antibacterial Activities |
| title_sort | new polyphenols from a deep sea spiromastix sp fungus and their antibacterial activities |
| topic | fungus from deep sea Spiromastix sp. spiromastols A–K polyphenols antibacterial activities |
| url | http://www.mdpi.com/1660-3397/13/4/2526 |
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