Long-Term Effects of Biliverdin Reductase a Deficiency in <i>Ugt1</i><sup>−/−</sup> Mice: Impact on Redox Status and Metabolism

Long-Term Effects of Biliverdin Reductase a Deficiency in <i>Ugt1</i><sup>−/−</sup> Mice: Impact on Redox Status and Metabolism

Accumulation of neurotoxic bilirubin due to a transient neonatal or persistent inherited deficiency of bilirubin glucuronidation activity can cause irreversible brain damage and death. Strategies to inhibit bilirubin production and prevent neurotoxicity in neonatal and adult settings seem promising....

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Bibliographic Details
Main Authors: Giulia Bortolussi, Xiaoxia Shi, Lysbeth ten Bloemendaal, Bhaswati Banerjee, Dirk R. De Waart, Gabriele Baj, Weiyu Chen, Ronald P. Oude Elferink, Ulrich Beuers, Coen C. Paulusma, Roland Stocker, Andrés F. Muro, Piter J. Bosma
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antioxidants
Subjects:
Crigler-Najjar
Gilbert
fetus
aging
Prdx2
triglycerides
Online Access:https://www.mdpi.com/2076-3921/10/12/2029

Internet

https://www.mdpi.com/2076-3921/10/12/2029

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