A New N-Substituted 1<i>H</i>-Isoindole-1,3(2<i>H</i>)-Dione Derivative—Synthesis, Structure and Affinity for Cyclooxygenase Based on In Vitro Studies and Molecular Docking

A New N-Substituted 1<i>H</i>-Isoindole-1,3(2<i>H</i>)-Dione Derivative—Synthesis, Structure and Affinity for Cyclooxygenase Based on In Vitro Studies and Molecular Docking

Isoindoline-1,3-dione derivatives constitute an important group of medicinal substances. In this study, nine new 1<i>H</i>-isoindole-1,3(2<i>H</i>)-dione derivatives and five potential pharmacophores were obtained in good yield (47.24–92.91%). The structure of the new imides...

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Bibliographic Details
Main Authors: Dominika Szkatuła, Edward Krzyżak, Paulina Stanowska, Magdalena Duda, Benita Wiatrak
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
phthalimide
arylpiperazine
cyclooxygenase inhibition
molecular docking
Online Access:https://www.mdpi.com/1422-0067/22/14/7678

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https://www.mdpi.com/1422-0067/22/14/7678

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