Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens

Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens

Allelic diversity of human leukocyte antigen (HLA) class II genes may help maintain humoral immunity against infectious diseases. In this study, we investigated germline genetic variation in classical HLA class II genes and employed a systematic, unbiased approach to explore the relative contributio...

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Bibliographic Details
Main Authors: Taushif Khan, Mahbuba Rahman, Ikhlak Ahmed, Fatima Al Ali, Puthen Veettil Jithesh, Nico Marr
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
human antibody repertoires
microbial infection
phage immunoprecipitation sequencing
human leukocyte antigen
major histocompatibility complex
polymorphisms
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.856497/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.856497/full

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