Growing Old Too Early: Skeletal Muscle Single Fiber Biomechanics in Ageing R349P Desmin Knock-in Mice Using the <i>MyoRobot</i> Technology

Growing Old Too Early: Skeletal Muscle Single Fiber Biomechanics in Ageing R349P Desmin Knock-in Mice Using the <i>MyoRobot</i> Technology

Muscle biomechanics relies on active motor protein assembly and passive strain transmission through cytoskeletal structures. The desmin filament network aligns myofibrils at the z-discs, provides nuclear–sarcolemmal anchorage and may also serve as memory for muscle repositioning following large stra...

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Bibliographic Details
Main Authors: Charlotte Pollmann, Michael Haug, Barbara Reischl, Gerhard Prölß, Thorsten Pöschel, Stefan J Rupitsch, Christoph S Clemen, Rolf Schröder, Oliver Friedrich
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
biomechatronics
desminopathy
R349P desmin
single fibers
skeletal muscle
Online Access:https://www.mdpi.com/1422-0067/21/15/5501

Internet

https://www.mdpi.com/1422-0067/21/15/5501

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