Clinical Study of Aspirin and Zileuton on Biomarkers of Tobacco-Related Carcinogenesis in Current Smokers

Clinical Study of Aspirin and Zileuton on Biomarkers of Tobacco-Related Carcinogenesis in Current Smokers

The chemopreventive effect of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) on lung cancer risk is supported by epidemiologic and preclinical studies. Zileuton, a 5-lipoxygenase inhibitor, has additive activity with NSAIDs against tobacco carcinogenesis in preclinical models. We h...

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Bibliographic Details
Main Authors: Linda L. Garland, José Guillen-Rodriguez, Chiu-Hsieh Hsu, Lisa E. Davis, Eva Szabo, Christopher R. Husted, Hanqiao Liu, Ashley LeClerc, Yuriy O. Alekseyev, Gang Liu, Julie E. Bauman, Avrum E. Spira, Jennifer Beane, Malgorzata Wojtowicz, H.-H. Sherry Chow
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
lung cancer
cancer prevention
aspirin
prostaglandin
zileuton
leukotriene
Online Access:https://www.mdpi.com/2072-6694/14/12/2893

Internet

https://www.mdpi.com/2072-6694/14/12/2893

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