UHRF1 inhibition epigenetically reprograms cancer stem cells to suppress the tumorigenic phenotype of hepatocellular carcinoma

UHRF1 inhibition epigenetically reprograms cancer stem cells to suppress the tumorigenic phenotype of hepatocellular carcinoma

Abstract Cancer stem cells (CSCs) contribute to tumor initiation, progression, and recurrence in many types of cancer, including hepatocellular carcinoma (HCC). Epigenetic reprogramming of CSCs has emerged as a promising strategy for inducing the transition from malignancy to benignity. Ubiquitin-li...

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Bibliographic Details
Main Authors: Yanchen Wang, Pengchao Hu, Fenfen Wang, Shaoyan Xi, Shasha Wu, Liangzhan Sun, Yuyang Du, Jingyi Zheng, Hui Yang, Mao Tang, Han Gao, Hao Luo, Yue Lv, Jingsong Yan, Xijun Ou, Yan Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05895-w

Internet

https://doi.org/10.1038/s41419-023-05895-w

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