Paricalcitol Improves the Angiopoietin/Tie-2 and VEGF/VEGFR2 Signaling Pathways in Adriamycin-Induced Nephropathy

Paricalcitol Improves the Angiopoietin/Tie-2 and VEGF/VEGFR2 Signaling Pathways in Adriamycin-Induced Nephropathy

Renal endothelial cell (EC) injury and microvascular dysfunction contribute to chronic kidney disease (CKD). In recent years, increasing evidence has suggested that EC undergoes an endothelial-to-mesenchymal transition (EndoMT), which might promote fibrosis. Adriamycin (ADR) induces glomerular endot...

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Bibliographic Details
Main Authors: Amanda Lima Deluque, Beatriz Magalhães Oliveira, Cláudia Silva Souza, Ana Lívia Dias Maciel, Heloísa Della Coletta Francescato, Cleonice Giovanini, Lucas Ferreira de Almeida, Francisco José Albuquerque de Paula, Roberto Silva Costa, José Antunes-Rodrigues, Terezila Machado Coimbra
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Nutrients
Subjects:
paricalcitol
endothelial toxicity
cell differentiation
angiopoietin-2
Tie-2 receptor
angiogenic factors
Online Access:https://www.mdpi.com/2072-6643/14/24/5316

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https://www.mdpi.com/2072-6643/14/24/5316

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