Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies

Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies

TAR DNA-binding protein 43 (TDP-43) is a major component of ubiquitin-positive inclusion of TDP-43 proteinopathies including amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitinated inclusions, which is now referred to as FTLD-TDP. TDP-43 in the aberrant inclusion is kn...

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Bibliographic Details
Main Authors: Yohei Iguchi, Masahisa Katsuno, Shinnosuke Takagi, Shinsuke Ishigaki, Jun-ichi Niwa, Masato Hasegawa, Fumiaki Tanaka, Gen Sobue
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Neurobiology of Disease
Subjects:
TAR DNA-binding protein 43 kDa (TDP-43)
TDP-43 proteinopathy
Oxidative stress
Glutathione depletion
Post-translational modification
Protein phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111003779

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http://www.sciencedirect.com/science/article/pii/S0969996111003779

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