Intracellular functions and motile properties of bi-directional kinesin-5 Cin8 are regulated by neck linker docking

Intracellular functions and motile properties of bi-directional kinesin-5 Cin8 are regulated by neck linker docking

In this study, we analyzed intracellular functions and motile properties of neck-linker (NL) variants of the bi-directional S. cerevisiae kinesin-5 motor, Cin8. We also examined – by modeling – the configuration of H-bonds during NL docking. Decreasing the number of stabilizing H-bonds resulted in p...

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Bibliographic Details
Main Authors: Alina Goldstein-Levitin, Himanshu Pandey, Kanary Allhuzaeel, Itamar Kass, Larisa Gheber
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
kinesin-5
mitotic spindle
microtubules
single molecule motility
antiparallel microtubule sliding
bi-directional motility
Online Access:https://elifesciences.org/articles/71036

Internet

https://elifesciences.org/articles/71036

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