Vaccine-Induced, High-Magnitude HIV Env-Specific Antibodies with Fc-Mediated Effector Functions Are Insufficient to Protect Infant Rhesus Macaques against Oral SHIV Infection

Vaccine-Induced, High-Magnitude HIV Env-Specific Antibodies with Fc-Mediated Effector Functions Are Insufficient to Protect Infant Rhesus Macaques against Oral SHIV Infection

ABSTRACT Improved access to antiretroviral therapy (ART) and antenatal care has significantly reduced in utero and peripartum mother-to-child human immunodeficiency virus (HIV) transmission. However, as breast milk transmission of HIV still occurs at an unacceptable rate, there remains a need to dev...

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Bibliographic Details
Main Authors: Alan D. Curtis, Pooja T. Saha, Maria Dennis, Stella J. Berendam, Pratamesh Ramasubramanian, Kaitlyn A. Cross, S. Munir Alam, Guido Ferrari, Pamela A. Kozlowski, Genevieve G. Fouda, Michael G. Hudgens, Koen K. A. Van Rompay, Justin Pollara, Sallie R. Permar, Kristina De Paris
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mSphere
Subjects:
ADCC
Fc-mediated antibody function
pediatric HIV vaccine
rhesus macaque
Online Access:https://journals.asm.org/doi/10.1128/msphere.00839-21

Internet

https://journals.asm.org/doi/10.1128/msphere.00839-21

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