A Small-Molecule Inhibitor of the Anthranilyl-CoA Synthetase PqsA for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa

A Small-Molecule Inhibitor of the Anthranilyl-CoA Synthetase PqsA for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa

ABSTRACT One of the challenges associated with the treatment of Pseudomonas aeruginosa infections is the high prevalence of multidrug resistance (MDR). Since conventional antibiotics are ineffective at treating such bacterial infections, innovative antibiotics acting upon novel targets or via mechan...

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Bibliographic Details
Main Authors: Jianwei Chen, Yaojia Lu, Fei Ye, Hongfang Zhang, Yonglie Zhou, Jiangtao Li, Qiang Wu, Xuewei Xu, Qihao Wu, Bin Wei, Huawei Zhang, Hong Wang
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
PqsA
P. aeruginosa
quorum sensing
quorum sensing inhibitor
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02764-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.02764-21

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