Hypoxia and ERα Transcriptional Crosstalk Is Associated with Endocrine Resistance in Breast Cancer

Hypoxia and ERα Transcriptional Crosstalk Is Associated with Endocrine Resistance in Breast Cancer

Estrogen receptor-alpha (ERα) is the driving transcription factor in 70% of breast cancers and its activity is associated with hormone dependent tumor cell proliferation and survival. Given the recurrence of hormone resistant relapses, understanding the etiological factors fueling resistance is of m...

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Bibliographic Details
Main Authors: Charly Jehanno, Pascale Le Goff, Denis Habauzit, Yann Le Page, Sylvain Lecomte, Estelle Lecluze, Frédéric Percevault, Stéphane Avner, Raphaël Métivier, Denis Michel, Gilles Flouriot
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
breast cancer
estrogen receptor alpha
endocrine resistance
hypoxia
Online Access:https://www.mdpi.com/2072-6694/14/19/4934

Internet

https://www.mdpi.com/2072-6694/14/19/4934

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