Synaptic and endosomal localization of active gamma-secretase in rat brain.

Synaptic and endosomal localization of active gamma-secretase in rat brain.

A key player in the development of Alzheimer's disease (AD) is the gamma-secretase complex consisting of at least four components: presenilin, nicastrin, Aph-1 and Pen-2. gamma-Secretase is crucial for the generation of the neurotoxic amyloid beta-peptide (Abeta) but also takes part in the proc...

Full description

Bibliographic Details
Main Authors: Susanne Frykman, Ji-Yeun Hur, Jenny Frånberg, Mikio Aoki, Bengt Winblad, Jarmila Nahalkova, Homira Behbahani, Lars O Tjernberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2812513?pdf=render

Internet

http://europepmc.org/articles/PMC2812513?pdf=render

Similar Items