Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells

Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells

Abstract Background The over-activation of adenosine A2A receptors (A2AR) is closely implicated in cognitive impairments of Alzheimer's disease (AD). Growing evidence shows that A2AR blockade possesses neuroprotective effects on AD. Spatial navigation impairment is an early manifestation of cog...

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Bibliographic Details
Main Authors: Qi Ji, Yang Yang, Yun Xiong, Ying-Jie Zhang, Jun Jiang, Li-Ping Zhou, Xiao-Hui Du, Chun-Xiang Wang, Zhi-Ru Zhu
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Spatial memory
Adenosine A2A receptors
LTP
Adult born granule cells
Online Access:https://doi.org/10.1186/s13195-023-01337-z

Internet

https://doi.org/10.1186/s13195-023-01337-z

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