3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets

3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets

Abstract Background State‐of‐the‐art 3‐dimensional (3D) electron microscopy approaches provide a new standard for the visualization of human platelet ultrastructure. Application of these approaches to platelets rapidly fixed prior to purification to minimize activation should provide new insights in...

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Bibliographic Details
Main Authors: Irina D. Pokrovskaya, Shilpi Yadav, Amith Rao, Emma McBride, Jeffrey A. Kamykowski, Guofeng Zhang, Maria A. Aronova, Richard D. Leapman, Brian Storrie
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
electron microscopy
hemostasis
platelet granules
platelet organelles
platelet ultrastructure
super‐resolution light microscopy
Online Access:https://doi.org/10.1002/rth2.12260

Internet

https://doi.org/10.1002/rth2.12260

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