Pros and Cons of Pharmacological Manipulation of cGMP-PDEs in the Prevention and Treatment of Breast Cancer

Pros and Cons of Pharmacological Manipulation of cGMP-PDEs in the Prevention and Treatment of Breast Cancer

The cyclic nucleotides, cAMP and cGMP, are ubiquitous second messengers responsible for translating extracellular signals to intracellular biological responses in both normal and tumor cells. When these signals are aberrant or missing, cells may undergo neoplastic transformation or become resistant...

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Bibliographic Details
Main Authors: Patrizia Di Iorio, Maurizio Ronci, Patricia Giuliani, Francesco Caciagli, Renata Ciccarelli, Vanni Caruso, Sarah Beggiato, Mariachiara Zuccarini
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
cyclic GMP (cGMP)
PKG
nitric oxide (NO)
soluble guanylate cyclase (sGC)
breast cancer
phosphodiesterase (PDE)
Online Access:https://www.mdpi.com/1422-0067/23/1/262

Internet

https://www.mdpi.com/1422-0067/23/1/262

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