The novel drug candidate S2/IAPinh improves survival in models of pancreatic and ovarian cancer

The novel drug candidate S2/IAPinh improves survival in models of pancreatic and ovarian cancer

Abstract Cancer selective apoptosis remains a therapeutic challenge and off-target toxicity has limited enthusiasm for this target clinically. Sigma-2 ligands (S2) have been shown to enhance the cancer selectivity of small molecule drug candidates by improving internalization. Here, we report the sy...

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Bibliographic Details
Main Authors: Takaomi Hagi, Suwanna Vangveravong, Rony Takchi, Qingqing Gong, S. Peter Goedegebuure, Herve Tiriac, Brian A. Van Tine, Matthew A. Powell, William G. Hawkins, Dirk Spitzer
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-56928-z

Internet

https://doi.org/10.1038/s41598-024-56928-z

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