Design, Synthesis, and Investigation of Cytotoxic Activity of <i>cis</i>-Vinylamide-Linked Combretastatin Analogues as Potential Anticancer Agents

Design, Synthesis, and Investigation of Cytotoxic Activity of <i>cis</i>-Vinylamide-Linked Combretastatin Analogues as Potential Anticancer Agents

The combretastatins (<i>cis</i>-stilbenoid molecules) have received significant interest because of their simple chemical structures, excellent antiproliferative activity, and novel anti-tubulin molecular mechanism of action. Significant efforts have been carried out aiming at stabilizin...

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Bibliographic Details
Main Authors: Tarfah Al-Warhi, Leena S. Alqahtani, Ghadi Alsharif, Matokah Abualnaja, Ola A. Abu Ali, Safa H. Qahl, Hussam Awwadh E. Althagafi, Fahad Alharthi, Ibrahim Jafri, Fahmy G. Elsaid, Ali A. Shati, Salman Aloufi, Eman Fayad, Islam Zaki, Martha M. Morcoss
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Symmetry
Subjects:
CA-4
<i>cis</i>-vinylamide
cytotoxicity
microtubule
cell cycle analysis
annexin V
Online Access:https://www.mdpi.com/2073-8994/14/10/2088

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https://www.mdpi.com/2073-8994/14/10/2088

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