Investigation of Antifungal Properties of Synthetic Dimethyl-4-Bromo-1-(Substituted Benzoyl) Pyrrolo[1,2-a] Quinoline-2,3-Dicarboxylates Analogues: Molecular Docking Studies and Conceptual DFT-Based Chemical Reactivity Descriptors and Pharmacokinetics Evaluation

Investigation of Antifungal Properties of Synthetic Dimethyl-4-Bromo-1-(Substituted Benzoyl) Pyrrolo[1,2-a] Quinoline-2,3-Dicarboxylates Analogues: Molecular Docking Studies and Conceptual DFT-Based Chemical Reactivity Descriptors and Pharmacokinetics Evaluation

<i>Candida albicans</i>, an opportunistic fungal pathogen, frequently colonizes immune-compromised patients and causes mild to severe systemic reactions. Only few antifungal drugs are currently in use for therapeutic treatment. However, evolution of a drug-resistant <i>C. albicans&...

Full description

Bibliographic Details
Main Authors: Vijayakumar Uppar, Sandeep Chandrashekharappa, Chandan Shivamallu, Sushma P, Shiva Prasad Kollur, Joaquín Ortega-Castro, Juan Frau, Norma Flores-Holguín, Atiyaparveen I. Basarikatti, Mallikarjun Chougala, Mrudula Mohan M, Govindappa Banuprakash, Jayadev, Katharigatta N. Venugopala, Belakatte P. Nandeshwarappa, Ravindra Veerapur, Abdulaziz A. Al-Kheraif, Abdallah M. Elgorban, Asad Syed, Kiran K. Mudnakudu-Nagaraju, Basavaraj Padmashali, Daniel Glossman-Mitnik
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
BQ molecules
pyrrolo[1,2-a] quinolone
indolizines
molecular docking
DFT—density functional theory
conceptual DFT
Online Access:https://www.mdpi.com/1420-3049/26/9/2722

Internet

https://www.mdpi.com/1420-3049/26/9/2722

Similar Items