DCLK1-mediated regulation of invadopodia dynamics and matrix metalloproteinase trafficking drives invasive progression in head and neck squamous cell carcinoma

DCLK1-mediated regulation of invadopodia dynamics and matrix metalloproteinase trafficking drives invasive progression in head and neck squamous cell carcinoma

Abstract Background HNSCC presents a significant health challenge due to its high mortality resulting from treatment resistance and locoregional invasion into critical structures in the head and neck region. Understanding the invasion mechanisms of HNSCC has the potential to guide targeted therapies...

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Bibliographic Details
Main Authors: Levi Arnold, Marrion Yap, Nathan Farrokhian, Laura Jackson, Michael Barry, Thuc Ly, Pachiappan Arjunan, Angela Kaczorowski-Worthley, Carter Tews, Avisha Pandey, Austin Morrison, Michael P. Washburn, David Standing, Juan P. Gomez, Nanda Kumar Yellapu, David Johnson, Linheng Li, Shahid Umar, Shrikant Anant, Sufi Mary Thomas
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Cancer
Subjects:
Doublecortin-like kinase 1
HNSCC
Invadopodia
Loco-regional invasion
Tumor microenvironment
Online Access:https://doi.org/10.1186/s12943-025-02264-3

Internet

https://doi.org/10.1186/s12943-025-02264-3

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