Critical role of interferon-α constitutively produced in human hepatocytes in response to RNA virus infection.

Several viruses are known to infect human liver and cause the hepatitis, but the interferon (IFN) response, a first-line defense against viral infection, of virus-infected hepatocytes is not clearly defined yet. We investigated innate immune system against RNA viral infection in immortalized human h...

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Bibliographic Details
Main Authors: Yoji Tsugawa, Hiroki Kato, Takashi Fujita, Kunitada Shimotohno, Makoto Hijikata
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089869&type=printable