scAbsolute: measuring single-cell ploidy and replication status

scAbsolute: measuring single-cell ploidy and replication status

Abstract Cancer cells often exhibit DNA copy number aberrations and can vary widely in their ploidy. Correct estimation of the ploidy of single-cell genomes is paramount for downstream analysis. Based only on single-cell DNA sequencing information, scAbsolute achieves accurate and unbiased measureme...

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Bibliographic Details
Main Authors: Michael P. Schneider, Amy E. Cullen, Justina Pangonyte, Jason Skelton, Harvey Major, Elke Van Oudenhove, Maria J. Garcia, Blas Chaves Urbano, Anna M. Piskorz, James D. Brenton, Geoff Macintyre, Florian Markowetz
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Genome Biology
Subjects:
Single-cell DNA sequencing
Singe-cell genomics
Ploidy estimation
Whole-genome doubling
Whole-genome duplication
Cell cycle stage
Online Access:https://doi.org/10.1186/s13059-024-03204-y

Internet

https://doi.org/10.1186/s13059-024-03204-y

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