Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration

Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration

Abstract Background Synapse degeneration is an early event in pathological frontotemporal lobar degeneration (FTLD). Consequently, a surrogate marker of synapse loss could be used to monitor early pathologic changes in patients with underlying FTLD. The aim of this study was to evaluate the relation...

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Bibliographic Details
Main Authors: Alba Cervantes González, David J. Irwin, Daniel Alcolea, Corey T. McMillan, Alice Chen-Plotkin, David Wolk, Sònia Sirisi, Oriol Dols-Icardo, Marta Querol-Vilaseca, Ignacio Illán-Gala, Miguel Angel Santos-Santos, Juan Fortea, Edward B. Lee, John Q. Trojanowski, Murray Grossman, Alberto Lleó, Olivia Belbin
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Molecular Neurodegeneration
Subjects:
Calsyntenin-1
Frontotemporal lobar degeneration
Frontotemporal dementia
Cerebrospinal fluid
Biomarker
TDP-43
Online Access:https://doi.org/10.1186/s13024-022-00534-y

Internet

https://doi.org/10.1186/s13024-022-00534-y

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