SARS-CoV-2 Within-Host and in vitro Genomic Variability and Sub-Genomic RNA Levels Indicate Differences in Viral Expression Between Clinical Cohorts and in vitro Culture

SARS-CoV-2 Within-Host and in vitro Genomic Variability and Sub-Genomic RNA Levels Indicate Differences in Viral Expression Between Clinical Cohorts and in vitro Culture

BackgroundLow frequency intrahost single nucleotide variants (iSNVs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been increasingly recognised as predictive indicators of positive selection. Particularly as growing numbers of SARS-CoV-2 variants of interest (VOI) and concern...

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Bibliographic Details
Main Authors: Jessica E. Agius, Jessica C. Johnson-Mackinnon, Winkie Fong, Mailie Gall, Connie Lam, Kerri Basile, Jen Kok, Alicia Arnott, Vitali Sintchenko, Rebecca J. Rockett
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Microbiology
Subjects:
within-host diversity
variants
sub-genomic RNA
SARS-CoV-2
iSNV
evolution
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.824217/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2022.824217/full

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