Notch signaling contributes to liver inflammation by regulation of interleukin-22-producing cells in hepatitis B virus infection

Notch signaling contributes to liver inflammation by regulation of interleukin-22-producing cells in hepatitis B virus infection

The mechanism of hepatitis B virus (HBV) induced liver inflammation is not fully elucidated. Notch signaling augmented IL-22 secretion in CD4+ T cells, and Notch-IL-22 axis fine-tuned inflammatory response. We previously demonstrated a proinflammatory role of interleukin (IL)-22 in HBV infection. Th...

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Bibliographic Details
Main Authors: Xin Wei, Jiu-Ping Wang, Chun-Qiu Hao, Xiao-Fei Yang, Lin-Xu Wang, Chang-Xing Huang, Xue-Fan Bai, Jian-Qi Lian, Ye Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Hepatitis B virus
Inflammation
innate lymphoid cells
interleukin-22
Notch signaling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00132/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00132/full

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