Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse

Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse

Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the MECP2 gene, in which older patients often develop parkinsonian features. Although Mecp2 has been shown to modulate the catecholaminergic metabolism of the RTT mouse model, little is known about the central dopaminergic...

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Bibliographic Details
Main Authors: Nicolas Panayotis, Michel Pratte, Ana Borges-Correia, Adeline Ghata, Laurent Villard, Jean-Christophe Roux
Format: Article
Language:English
Published: Elsevier 2011-02-01
Series:Neurobiology of Disease
Subjects:
Rett syndrome
A9
Caudate–putamen
Mecp2
Tyrosine hydroxylase
Dopamine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003402

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http://www.sciencedirect.com/science/article/pii/S0969996110003402

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