Targeting Cell Cycle in Breast Cancer: CDK4/6 Inhibitors

Targeting Cell Cycle in Breast Cancer: CDK4/6 Inhibitors

Deregulation of cell cycle, via cyclin D/CDK/pRb pathway, is frequently observed in breast cancer lending support to the development of drugs targeting the cell cycle control machinery, like the inhibitors of the cycline-dependent kinases (CDK) 4 and 6. Up to now, three CDK4/6 inhibitors have been a...

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Bibliographic Details
Main Authors: Michela Piezzo, Stefania Cocco, Roberta Caputo, Daniela Cianniello, Germira Di Gioia, Vincenzo Di Lauro, Giuseppina Fusco, Claudia Martinelli, Francesco Nuzzo, Matilde Pensabene, Michelino De Laurentiis
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
cell cycle
cyclin-dependent kinase
cancer
metastatic breast cancer
hormone therapy
CDK4/6 inhibitors
Online Access:https://www.mdpi.com/1422-0067/21/18/6479

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https://www.mdpi.com/1422-0067/21/18/6479

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