A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells

A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells

Summary: Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) not only suppress PARP1 catalytic activity but also prolong its association to damaged chromatin. Here, through live-cell imaging, we quantify the alterations in PARP1 dynamics and activity elicited by seven PARPis over a wide range of...

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Detaylı Bibliyografya
Asıl Yazarlar: Petar-Bogomil Kanev, Sylvia Varhoshkova, Irina Georgieva, Maria Lukarska, Dilyana Kirova, Georgi Danovski, Stoyno Stoynov, Radoslav Aleksandrov
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Elsevier 2024-05-01
Seri Bilgileri:Cell Reports
Konular:
CP: Cancer
CP: Molecular biology
Online Erişim:http://www.sciencedirect.com/science/article/pii/S221112472400562X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472400562X

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