Design, Cytotoxicity and Antiproliferative Activity of 4-Amino-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylates against MFC-7 and MDA-MB-231 Breast Cancer Cell Lines

Design, Cytotoxicity and Antiproliferative Activity of 4-Amino-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylates against MFC-7 and MDA-MB-231 Breast Cancer Cell Lines

Novel 4-amino-thieno[2,3-d]pyrimidine-6-carboxylates substituted at the second position were prepared by cyclocondensation of 2-amino-3-cyano-thiophene and aryl nitriles in an acidic medium. The design of the target compounds was based on structural optimization. The derivatives thus obtained were t...

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Bibliographic Details
Main Authors: Anelia Mavrova, Stephan Dimov, Inna Sulikovska, Denitsa Yancheva, Ivan Iliev, Iana Tsoneva, Galya Staneva, Biliana Nikolova
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
4-amino-thienopyrimidines
cytotoxicity
phototoxicity
antiproliferation
molecular structure
structure–activity relationship
Online Access:https://www.mdpi.com/1420-3049/27/10/3314

Internet

https://www.mdpi.com/1420-3049/27/10/3314

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