Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication

Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication

Abstract Background In all living organisms, DNA replication is exquisitely regulated in a wide range of growth conditions to achieve timely and accurate genome duplication prior to cell division. Failures in this regulation cause DNA damage with potentially disastrous consequences for cell viabilit...

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Bibliographic Details
Main Authors: Steff Horemans, Matthaios Pitoulias, Alexandria Holland, Emilie Pateau, Christophe Lechaplais, Dariy Ekaterina, Alain Perret, Panos Soultanas, Laurent Janniere
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Biology
Subjects:
Replication timing
Central carbon metabolism
Glycolytic enzymes
Replication enzymes
Cell cycle
Allosteric regulation
Online Access:https://doi.org/10.1186/s12915-022-01278-3

Internet

https://doi.org/10.1186/s12915-022-01278-3

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