CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

Abstract Background The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested the involvement of CCL2 and tumor associated macrophages (TAMs) in esophageal carcinogenesis. Despite the recognition of TAM...

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Bibliographic Details
Main Authors: Hui Yang, Qiannan Zhang, Miao Xu, Lei Wang, Xuewei Chen, Yongquan Feng, Yongning Li, Xin Zhang, Wenming Cui, Xudong Jia
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Molecular Cancer
Subjects:
CCL2
CCR2
Carcinogenesis
Esophageal squamous cell carcinoma (ESCC)
Programmed death-1(PD-1)
Tumor associated macrophages (TAMs)
Online Access:http://link.springer.com/article/10.1186/s12943-020-01165-x

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http://link.springer.com/article/10.1186/s12943-020-01165-x

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