Blocking RAGE expression after injury reduces inflammation in mouse model of acute lung injury

Blocking RAGE expression after injury reduces inflammation in mouse model of acute lung injury

Abstract Background Receptor for Advanced Glycated Endproducts (RAGE) plays a major role in the inflammatory response to infectious and toxin induced acute lung injury. We tested the hypothesis that a RAGE blocking antibody when administered after the onset of injury can reduce lung inflammation com...

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Bibliographic Details
Main Authors: Lynne L. Johnson, Yared Tekabe, Tina Zelonina, Xinran Ma, Geping Zhang, Monica Goldklang, Jeanine D’Armiento
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Respiratory Research
Subjects:
Acute lung injury
RAGE
Mice
Treatment
Antibodies
Online Access:https://doi.org/10.1186/s12931-023-02324-6

Internet

https://doi.org/10.1186/s12931-023-02324-6

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