The use of lentiviral vectors and Cre/loxP to investigate the function of genes in complex behaviors

The use of conventional knockout (KO) technologies has proved valuable for understanding the role of key genes and proteins in development, disease states, and complex behaviors. However, these strategies are limited in that they produce broad changes in gene function throughout the neuroaxis and do...

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Bibliographic Details
Main Authors: Scott Heldt, Kerry Ressler
Format: Article
Language:English
Published: Frontiers Media S.A. 2009-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/neuro.02.022.2009/full