Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7

Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7

Abstract Background Tyrosine kinase inhibitors (TKIs) that specifically target mutational points in the EGFR gene have significantly reduced suffering and provided greater relief to patients with lung adenocarcinoma (LUAD). The third-generation EGFR-TKI, Osimertinib, has been successfully employed i...

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Bibliographic Details
Main Authors: Kai Li, Zi-Yang Peng, Rui Wang, Xiang Li, Ning Du, Da-Peng Liu, Jia Zhang, Yun-Feng Zhang, Lei Ma, Ye Sun, Shou-Ching Tang, Hong Ren, Yi-Ping Yang, Xin Sun
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Molecular Cancer
Subjects:
Translated circRNAs
m6A modification
Tyrosine kinase inhibitor
Lung adenocarcinoma
Therapy resistance
Online Access:https://doi.org/10.1186/s12943-023-01811-0

Internet

https://doi.org/10.1186/s12943-023-01811-0

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