Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)

Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)

Abstract Heat shock protein 90 (Hsp90) and its co-chaperones promote cancer, and targeting Hsp90 holds promise for cancer treatment. Most of the efforts to harness this potential have focused on targeting the Hsp90 N-terminus ATP binding site. Although newer-generation inhibitors have shown improved...

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Bibliographic Details
Main Authors: Chaitanya A. Patwardhan, Vamsi Krishna Kommalapati, Taoufik Llbiyi, Digvijay Singh, Eyad Alfa, Anatolij Horuzsko, Hasan Korkaya, Siva Panda, Christopher A. Reilly, Vladimir Popik, Ahmed Chadli
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-40933-9

Internet

https://doi.org/10.1038/s41598-023-40933-9

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