Elucidating the Inhibitory Potential of Designed Peptides Against Amyloid Fibrillation and Amyloid Associated Cytotoxicity

Elucidating the Inhibitory Potential of Designed Peptides Against Amyloid Fibrillation and Amyloid Associated Cytotoxicity

Inhibition of fibrillation process and disaggregation of mature fibrils using small peptide are the promising remedial strategies to combat neurodegenerative diseases. However, designing peptide-based drugs to target β-sheet-rich amyloid has been a major challenge. The current work describes, for th...

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Bibliographic Details
Main Authors: Mohammad K. Siddiqi, Parvez Alam, Tabish Iqbal, Nabeela Majid, Sadia Malik, Saima Nusrat, Aftab Alam, Mohd R. Ajmal, Vladimir N. Uversky, Rizwan H. Khan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Chemistry
Subjects:
amyloid
inhibitor
thioflavin T assay
hemolysis
TEM
human insulin
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00311/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2018.00311/full

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