Analysis and comparison of post-translational modifications of α-synuclein filaments in multiple system atrophy and dementia with Lewy bodies

Analysis and comparison of post-translational modifications of α-synuclein filaments in multiple system atrophy and dementia with Lewy bodies

Abstract Our previous cryogenic electron microscopy (cryoEM) analysis showed that the core structures of α-synuclein filaments accumulated in brains of patients diagnosed with dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) patients are different. We analyzed the post-translational...

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Bibliographic Details
Main Authors: Fuyuki Kametani, Marina Tahira, Masaki Takao, Tomoyasu Matsubara, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Masato Hasegawa
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
α-Synuclein
Multiple system atrophy
Dementia with Lewy bodies
Cryogenic electron microscopy
Mass spectrometry
Post-translational modification
Online Access:https://doi.org/10.1038/s41598-024-74130-z

Internet

https://doi.org/10.1038/s41598-024-74130-z

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