In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

An in silico drug discovery pipeline for the virtual screening of plant-origin natural products (NPs) was developed to explore new direct inhibitors of TNF and its close relative receptor activator of nuclear factor kappa-B ligand (RANKL), both representing attractive therapeutic targets for many ch...

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Bibliographic Details
Main Authors: Georgia Melagraki, Evangelos Ntougkos, Dimitra Papadopoulou, Vagelis Rinotas, Georgios Leonis, Eleni Douni, Antreas Afantitis, George Kollias
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
direct TNF inhibitors
RANKL inhibitors
natural products
autoimmune diseases
virtual screening
molecular dynamics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00800/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00800/full

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