A clinical evaluation of an ex vivo organ culture system to predict patient response to cancer therapy

A clinical evaluation of an ex vivo organ culture system to predict patient response to cancer therapy

IntroductionEx vivo organ cultures (EVOC) were recently optimized to sustain cancer tissue for 5 days with its complete microenvironment. We examined the ability of an EVOC platform to predict patient response to cancer therapy.MethodsA multicenter, prospective, single-arm observational trial. Sampl...

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Main Authors: Shay Golan, Vered Bar, Seth J. Salpeter, Guy Neev, German Creiderman, Daniel Kedar, Sara Aharon, Lubov Turovsky, Adi Zundelevich, Hamutal Shahar, Hagit Shapira, Giuseppe Mallel, Erez Stossel, Nancy Gavert, Ravid Straussman, Zohar Dotan, Raanan Berger, Chani Stossel, Talia Golan, Sharon Halperin, Dan Leibovici, Shani Breuer, Yakir Rottenberg, Liat Applebaum, Ayala Hubert, Hovav Nechushtan, Tamar Peretz, Aviad Zick, Boris Chertin, Dmitry Koulikov, Amir Sonnenblick, Eli Rosenbaum
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Medicine
Subjects:
cancer
solid tumors
ex vivo organ culture
clinical response
prediction of treatment response
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1221484/full

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https://www.frontiersin.org/articles/10.3389/fmed.2023.1221484/full

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