STXBP6 and B3GNT6 Genes are Associated With Selective IgA Deficiency

STXBP6 and B3GNT6 Genes are Associated With Selective IgA Deficiency

Immunoglobulin A Deficiency (IgAD) is a polygenic primary immune deficiency, with a strong genetic association to the human leukocyte antigen (HLA) region. Previous genome-wide association studies (GWAS) have identified five non-HLA risk loci (IFIH1, PVT1, ATG13-AMBRA1, AHI1 and CLEC16A). In this st...

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Bibliographic Details
Main Authors: Che Kang Lim, Paola G. Bronson, Jezabel Varade, Timothy W. Behrens, Lennart Hammarström
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Genetics
Subjects:
immunoglobulin a deficiency
major histocompatibility complex (MHC)
non-MHC genes
HLA risk allele
Stratification
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.736235/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.736235/full

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