A SUMOylation-dependent HIF-1α/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis

A SUMOylation-dependent HIF-1α/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis

Abstract Background We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly recognized factor that promotes tumor metastasis. In this study, we aim to explain this confusing finding and delineate the...

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Bibliographic Details
Main Authors: Yiyang Jia, Yantong Guo, Qiu Jin, Huinan Qu, Da Qi, Peiye Song, Xiaoli Zhang, Xinqi Wang, Wenhong Xu, Yuan Dong, Yingying Liang, Chengshi Quan
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Breast cancer
CLDN6
HIF-1α
SUMOylation
Tumor metastasis
Online Access:http://link.springer.com/article/10.1186/s13046-020-01547-5

Internet

http://link.springer.com/article/10.1186/s13046-020-01547-5

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