Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation

Direct regulation of the cardiac ryanodine receptor (RyR2) by O-GlcNAcylation

Abstract Background O-GlcNAcylation is the enzymatic addition of a sugar, O-linked β-N-Acetylglucosamine, to the serine and threonine residues of proteins, and is abundant in diabetic conditions. We have previously shown that O-GlcNAcylation can trigger arrhythmias by indirectly increasing pathologi...

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Bibliographic Details
Main Authors: Chidinma A Okolo, Ei-Phyo Khaing, Valeria Mereacre, Rachel S Wallace, Michelle L Munro, Jeffrey R Erickson, Peter P. Jones
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cardiovascular Diabetology
Subjects:
Ryanodine receptor (RyR2)
O-GlcNAcylation
SOICR
Diabetes
Online Access:https://doi.org/10.1186/s12933-023-02010-3

Internet

https://doi.org/10.1186/s12933-023-02010-3

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