Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer

Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer

Abstract Background Epigenetic information can be used to identify clinically relevant genomic variants single nucleotide polymorphisms (SNPs) of functional importance in cancer development. Super-enhancers are cell-specific DNA elements, acting to determine tissue or cell identity and driving tumor...

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Bibliographic Details
Main Authors: Verena Zuber, Francesco Bettella, Aree Witoelar, the PRACTICAL Consortium, the CRUK GWAS, the BCAC Consortium, the TRICL Consortium, Ole A. Andreassen, Ian G. Mills, Alfonso Urbanucci
Format: Article
Language:English
Published: BMC 2017-03-01
Series:BMC Genomics
Subjects:
BRD4
Genome-wide association studies
SNPs
Functional annotation
Chromatin
Risk loci
Online Access:http://link.springer.com/article/10.1186/s12864-017-3620-y

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http://link.springer.com/article/10.1186/s12864-017-3620-y

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