Factors influencing plasma concentration of voriconazole and voriconazole- N-oxide in younger adult and elderly patients

Factors influencing plasma concentration of voriconazole and voriconazole- N-oxide in younger adult and elderly patients

Background: Voriconazole (VCZ) metabolism is influenced by many factors. Identifying independent influencing factors helps optimize VCZ dosing regimens and maintain its trough concentration (C0) in the therapeutic window.Methods: We conducted a prospective study investigating independent factors inf...

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Bibliographic Details
Main Authors: Lin Cheng, Zaiming Liang, Fang Liu, Ling Lin, Jiao Zhang, Linli Xie, Mingjie Yu, Fengjun Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
voriconazole
voriconazole-N-oxide
total bile acid
platelet count
estimated glomerular filtration rate
IL-6
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1126580/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1126580/full

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