Factors influencing plasma concentration of voriconazole and voriconazole- N-oxide in younger adult and elderly patients

Factors influencing plasma concentration of voriconazole and voriconazole- N-oxide in younger adult and elderly patients

Background: Voriconazole (VCZ) metabolism is influenced by many factors. Identifying independent influencing factors helps optimize VCZ dosing regimens and maintain its trough concentration (C0) in the therapeutic window.Methods: We conducted a prospective study investigating independent factors inf...

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Bibliographic Details
Main Authors:	Lin Cheng, Zaiming Liang, Fang Liu, Ling Lin, Jiao Zhang, Linli Xie, Mingjie Yu, Fengjun Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Series:	Frontiers in Pharmacology
Subjects:	voriconazole voriconazole-N-oxide total bile acid platelet count estimated glomerular filtration rate IL-6
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1126580/full

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