A c-Myc/miR17-92/Pten Axis Controls PI3K-Mediated Positive and Negative Selection in B Cell Development and Reconstitutes CD19 Deficiency

A c-Myc/miR17-92/Pten Axis Controls PI3K-Mediated Positive and Negative Selection in B Cell Development and Reconstitutes CD19 Deficiency

PI3K activity determines positive and negative selection of B cells, a key process for immune tolerance and B cell maturation. Activation of PI3K is balanced by phosphatase and tensin homolog (Pten), the PI3K’s main antagonistic phosphatase. Yet, the extent of feedback regulation between PI3K activi...

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Bibliographic Details
Main Authors: David Benhamou, Verena Labi, Rostislav Novak, Isabelle Dai, Shani Shafir-Alon, Ariel Weiss, Renaud Gaujoux, Rüdiger Arnold, Shai S. Shen-Orr, Klaus Rajewsky, Doron Melamed
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306970

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http://www.sciencedirect.com/science/article/pii/S2211124716306970

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