Endothelial damage and a thin intercellular fibrin network promote haemorrhage in acute promyelocytic leukaemia

Endothelial damage and a thin intercellular fibrin network promote haemorrhage in acute promyelocytic leukaemia

Background: The role of vascular endothelium in acute promyelocytic leukaemia (APL) remains unknown. We aimed to investigate the mechanisms by which APL cells interact with endothelial cells (ECs) and to further explore how the endothelium affects bleeding as well as therapeutic interventions. Metho...

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Bibliographic Details
Main Authors: Chunxu Wang, Muxin Yu, Peng Zhou, Baorong Li, Yingmiao Liu, Lixiu Wang, Xiaojing Chen, Jingwen Du, Yufeng Wang, Jinming Zhang, Haijiao Jing, Yiming Feng, Yue Zhang, Yueyue Li, Zengxiang Dong, Shaohong Fang, Valerie A Novakovic, Jin Zhou, Jialan Shi
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:EBioMedicine
Subjects:
Acute promyelocytic leukaemia
Endothelial cells
Permeability
Fibrin
Haemorrhage
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303686

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http://www.sciencedirect.com/science/article/pii/S2352396420303686

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