The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy

The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy

Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells induces eNOS (endothelial nitric oxide synthase) expression, subsequent NO (nitric oxide) release, and vasodilatory e...

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Bibliographic Details
Main Authors: Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Andrey V. Grechko, Nikolay K. Shakhpazyan, Alexander N. Orekhov
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomedicines
Subjects:
atherosclerosis
Kruppel like factor 2
inflammation
atheroprotection
shear stress
Online Access:https://www.mdpi.com/2227-9059/10/2/254

Internet

https://www.mdpi.com/2227-9059/10/2/254

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