Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity

Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity

Abstract Background MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers. A plethora of drugs were developed to block this kinase pathway for clinical application. With...

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Bibliographic Details
Main Authors: Ning Wang, Yanhua Fan, Chun-Mao Yuan, Jialei Song, Yao Yao, Wuling Liu, Babu Gajendran, Eldad Zacksenhaus, Yanmei Li, Jielin Liu, Xiao Jiang Hao, Yaacov Ben-David
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Cancer
Subjects:
Cancer
Leukemia
Chinese medicinal plant
Melia azedarach
Drug screen
ERK1/2 agonists
Online Access:http://link.springer.com/article/10.1186/s12885-019-5914-8

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http://link.springer.com/article/10.1186/s12885-019-5914-8

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